Patients with OSCC and high density of FoxP3+ T-cells in the IF of tumor parenchyma showed significantly increased OS (91.7% vs. 73.8%, p = 0.006), DSS (95.8% vs. 84.6%, p = 0.02), RFS (73.6% vs. 50.8%, p = 0.008), and MFS (87.7% vs. 70.6%, p = 0.02). Here, FOXP3 is linked to neoplasm.