In the in vitro studies, we observed that infection with Beau-R, M41-CK and D388 elicit significant upregulation of IFN-α, IFN-β and chIFITMs. Interferon and chIFITM gene response to M41-CK and D388 infection in CK cells displayed a gradual increase in expression from 12 hpi to 36 hpi, with levels reaching statistical significance at 24 hpi while in Beau-R-infected CK cells, IFITM and IFN response is relatively low and at similar levels at 12 and 24 hpi but an increased IFITM and IFN response is observed at 36 hpi. This evidence concerns the gene IFNB1 and infection.