CXCL10 and obesity due to melanocortin 4 receptor deficiency: Given that the mainly prominent downregulated genes (Iigp1 and Cxcl10) play critical roles in immunoregulation and inflammation, these findings suggest that HFD-induced obesity suppresses the ability of mammary stromal fibroblasts to express and secrete these immunoregulatory and inflammatory proteins/cytokines to compromise the immunity of mammary glands.