Truncal TP53 p.Y220C (case 5) and PIK3CA p.H1047R (case 9) mutations were identified in primary and recurrent tumors but additional mutations, MET p.T1010I, FGFR2 p.S252W, and KRAS p.G12A, were detected in the ctDNA at recurrence that were not present in the tumor samples (Table S2). Here, PIK3CA is linked to neoplasm.