PGR and breast cancer: Interestingly, genes in the black module were enriched for the PR action in breast cancer: stimulation of cell growth and proliferation pathway (FDR = 9.05 × 10−3), inhibition of LKB1/AMPK signaling in breast cancer pathway (FDR = 1.37 × 10−2), and IL-6 signaling in breast cancer cells pathway (FRD = 2.48 × 10−2) (Figure 4D and Table S6).