Attempting to reproduce molecular classifications, Setia et al. examined 14 protein and mRNA expression biomarkers and identified five subgroups of GC characterized by Epstein–Barr virus positivity, microsatellite instability, aberrant E-cadherin and p53 expression corresponding to molecular subtypes in TCGA and ACRG systems (N = 146). The gene discussed is CDH1; the disease is gastric cancer.