Several other meningitis causing bacteria have been reported to enter the brain via the CP in vivo [44,45,46,47,48,49,50,51,52,53,54,55] and in vitro [43,56,57,58,59], allowing the conclusion that penetration of the BCSFB constituted by the epithelial lining of the CP epithelial cells from the blood to the brain is a pathophysiological step from bacteremia to meningitis [56,57]. The gene discussed is CP; the disease is bacterial infectious disease with sepsis.