The protein abundance ratio of HF/Chow was >1 in 12 out of the 13 collagen isoforms detected in the skeletal muscle, while Col24α1, Col1α1, Col1α2, Col3α1, Col2α1 and Col5α2 were increased by >2-fold in the HF-fed mice relative to chow-fed control mice (Figure 1A). The gene discussed is COL2A1; the disease is hydrops fetalis.