Our results showed that in skeletal muscle, differentially increased proteins were mainly collagen isoform clusters, which were highly involved in pathways including protein digestion and absorption, ECM–receptor interaction, amoebiasis, platelet activation, focal adhesion and PI3K (Phosphoinositide 3-kinase)-Akt (Protein kinase B) signalling pathway (Table 1). This evidence concerns the gene AKT1 and amebiasis.