SLCO1B1 and Hepatic failure: Reduced levels of the canalicular transporter MRP2, accompanied by decreased abundance of basolateral (sinusoidal) uptake transporters (OATP1B1, OATP1B3, and NTCP) and increased values of efflux transporters (P-gp, MRP4) most likely represent adaptive changes of hepatocytes providing a defense mechanism against bile salts in hepatic insufficiency.