ABCC2 and pulmonary arterial hypertension: Tanaka et al. [62] not only confirmed increased Mrp2 protein levels and mRNA expression in the kidneys 24 h after BDL (in the liver Abcc2/Mrp2 protein and mRNA expression were downregulated), but also reported an increased renal Mrp2 function assessed via PAH clearance in a rat model of obstructive jaundice.