NUCLEOLIN and cancer: Finally, since an effective treatment for breast cancer would require targeting both cancer stem cells (CSCs) and non-stem cancer cells (n-SCCs), as the second may also originate CSCs through epithelial-to-mesenchymal transition [157], Fonseca et al. showed that F3-functionalized pH-sensitive liposomes were able to target simultaneously nucleolin-overexpressing CSCs and non-SCCs [156].