CXCL8 and chronic obstructive pulmonary disease: In the study reported by Shi et al. (2018), this compound improved chronic obstructive pulmonary disease by decreasing interleukin-8 (IL-8), TNF-α, and monocyte chemoattractant protein-1 (MCP1) levels, as well as by increasing enzymatic antioxidant defenses in mice [54].