Among 354 patients with a diagnosis of NASH cirrhosis at the Mayo Clinic, Rochester, diabetes (HR = 4.2; 95% CI = 1.2–14.2; p = 0.02), age (per decade, HR = 1.8; 95% CI = 1.2–2.6; p < 0.01), and low serum albumin (HR = 2.1; 95% CI = 1.5–2.9; p < 0.01) were significantly associated with an increased risk of developing HCC in a multivariable analysis. The gene discussed is ALB; the disease is hepatocellular carcinoma.