PNPLA3 and diabetes mellitus: Advanced fibrosis (F3/4), old age, male gender, low platelets (less than 150,000/μL), high AST, diabetes, and the patatin-like phospholipase domain-containing protein 3 (PNPLA3) single nucleotide polymorphism (SNP) GG homozygote have been established as carcinogenic risk factors in Japan [9,19,21].