Moreover, luteolin and luteolin-enriched artichoke leaf extract administered to HFD-fed mice prevented hepatic steatosis (less and smaller lipid droplets, lower levels of Cidea) and insulin resistance by suppressing lipogenesis and gluconeogenesis (suppression of PEPCK and G6Pase activities) and increasing FAO (more CPT1a activity and higher expression of Pparα, Pgc1α and Pgc1β) [342]. This evidence concerns the gene INS and fatty liver disease.