Mulberry anthocyanin extract administration to type 2 diabetic mice increased the activity of AMPK/peroxisome proliferator-activated receptor gamma coactivator 1 alfa (PGC1α)/p38 mitogen-activated protein kinase (MAPK) and reduced the activity of the acetyl-CoA carboxylase enzyme (ACC), a rate-limiting enzyme of fatty acid synthesis, and of the mammalian target of rapamycin (mTOR) that is involved in protein synthesis regulation and insulin signaling [96]. This evidence concerns the gene ACACA and type 2 diabetes mellitus.