FASN and obesity due to melanocortin 4 receptor deficiency: Similar effects were described in HFD-fed hamsters, where Mulberry water extracts exerted anti-obesity effects by inhibiting lipogenesis (downregulation of fatty acid synthase (FASN) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase) and upregulating PPARα and CPT1A [81].