PPARG and obesity due to melanocortin 4 receptor deficiency: On the other side, apigenin may act as a PPARγ modulator in a mouse model of obesity where it activated the p65/PPARγ complex translocation into the nucleus, thereby decreasing the NF-κB activation and favoring the M2 macrophage polarization [356] or blocking NLRP3 inflammasome assembly and the ROS production [357].