A similar effect on NAFLD has been described with Puerarin, a major bioactive isoflavone compound isolated from the roots of the Pueraria lobata. Puerarin attenuated NAFLD development in high fat/high sucrose-fed mice via the activation of the Poly(ADP-ribose) polymerase 1 (PARP-1)/PI3K/Akt signaling pathway and lately the improvement of the mitochondrial function [311]. The gene discussed is PARP1; the disease is metabolic dysfunction-associated steatotic liver disease.