This was seen during cellular senescence and leads to CENP-A mislocalization and mitotic arrest [255] in aging cells [256,257,258,259], in cells overexpressing Myc proto-oncogene protein (MYC), under an ectopic interaction with CENP-A [260], and with a corresponding de-repression of centromeric TEs (frequently observed in many cancers) [261,262]. Here, MYC is linked to cancer.