Recently studies have shown that KIF15 methylation may play important role in the pathogenesis of AF through the regulation of the expression of proteasome 26S subunit ATPase 3 (PSMC3), tubulointerstitial nephritis antigen (TINAG), and nudix hydrolase 6 (NUDT6) [209]. Here, PSMC3 is linked to atrial fibrillation.