IFNA1 and neoplasm: Upregulation of immune response pathways related mostly to B cells and IFN (both 1 [i.e., alpha] and 2 [i.e., gamma]) in good responders may reflect the presence of a competent adaptive immune system ready to activate an effective antitumor response once the nCRT starts damaging tumor cells and liberating immune attractors such as damage-associated molecular patterns (DAMPs) and/or neoantigens [42].