The role of EMT in PC metastasis has been studied [17,56], revealing significant interplay between EMT-related genes and alterations in signaling pathways involved in prostate organogenesis, such as transforming growth factor-beta (TGF-β) [57], epidermal growth factor receptor (EGFR) [58], IL-6 [59,60], AR variants [61,62], fibroblast growth factor (FGF) [63], and Wnt/β-catenin [64,65]. This evidence concerns the gene TGFB1 and pachyonychia congenita.