Unsurprisingly, loss of expression of these PTAs, which is driven by the transcription factors autoimmune regulator (AIRE), deformed epidermal autoregulatory factor 1 (DEAF1), and FEZ family zinc finger 2 (Fezf2) [10,11,12,13], leads to autoimmunity [10,12,14]. The gene discussed is AIRE; the disease is Autoimmunity.