Additionally, toll-like receptors (TLR7 and TLR9) on pDCs were shown to directly kill breast cancer cells through TNF-related apoptosis-inducing ligand (TRAIL) and Granzyme B in a breast cancer mouse model and ultimately inhibit breast tumor growth by initiating the sequential activation of NK cells and CD8+ T cells [53]. The gene discussed is CD8A; the disease is breast carcinoma.