In mice, tumor-migrating DCs are thought to be required for de novo T cell priming in the lymph nodes, which can be divided based on specific markers into two lineages: the minor CD8α/CD103+ cDC1 population that depends on the transcription factors interferon regulatory factor (IRF) 8 and basic leucine zipper transcription factor ATF-like 3 (BATF3) and the predominant CD11b+ cDC2 population relying on the transcription factor IRF4 [49,50]. Here, CD8A is linked to neoplasm.