It was reported that CDDP inhibits significantly NF-κB activity by suppressing p-IκB in CDDP-sensitive cancer cells and that an inhibitor of NF-κB that blocks IκB phosphorylation showed overcome relative CDDP resistance, even though CDDP usually suppresses NF-κB activity in cancer cells [19,29]. The gene discussed is NFKB1; the disease is cancer.