Readers can refer to recent reviews [11,12] for an updated discussion of the pleiotropic toxic effects of copper imbalance in AD and its implication in brain antioxidant stress, abnormal Aβ, and tau misfolding/aggregation, as well as aberrant mitochondrial function and energy production postulated at the basis of AD neurodegeneration. The gene discussed is MAPT; the disease is Alzheimer disease.