The decreased methylation of the investigated TSS1500 and TSS200 regions might be beneficial in some cases, as hypermethylation were in concordance with tumor progression in certain genes (DTX1 [31], GATA4 [32], SEZ6L [33], TP53INP1 [34], HAAO [35], TAL1 [36]) associated with the top 10 hypomethylated probes localized in promoters. This evidence concerns the gene GATA4 and neoplasm.