A combination of miR-100 and miR-200b was proved to outperform the capability of serum PSA to predict PCa using the whole study cohort (AUC = 0.738 vs. 0.681, ACC = 75.5% vs. 67.8%) as well as the sub-group of patients in the PSA gray zone of 4–10 ng/mL (AUC = 0.827 vs. 0.590, ACC = 80.5% vs. 68.8%). Here, KLK3 is linked to posterior cortical atrophy.