EZH2 and neoplasm: Regarding miR-26a, we previously showed that this miRNA is significantly downregulated in PCa tissue samples and could exert tumor-suppressive functions possibly by regulating genes that are upregulated in PCa, such as alpha-methylacyl-CoA racemase (AMACR) and enhancer of zeste homolog 2 (EZH2) [13,45].