CNTNAP2 and autism: Both Coutinho et al. and Brimberg et al. describe a CASPR2-Ab-induced autism-like phenotype, but Coutinho et al. did not find CASPR2-Abs in patients with autism diagnosed in the 1990s; it is possible, therefore, that CASPR2-Abs are associated with the wider spectrum disorder rather than the classically defined disease.