Alternatively, spliced transcripts between aging and MDS/AML stem cells include genes already shown to be differentially spliced in blast crisis (BC) versus chronic phase (CP) of CML: BCL-X, PTK2B, ITGB2, CD44 or PTPN6. This evidence concerns the gene BCL2L1 and chronic myelogenous leukemia, BCR-ABL1 positive.