Jiménez-Osorio et al. [202] failed to observe any effects of curcumin (320 mg/d for 8 weeks) on the activities of NRF2 target genes (glutathione peroxidase, glutathione reductase, superoxide dismutase (SOD), and catalase) in peripheral blood mononuclear cells (PBMCs) of diabetic proteinuric chronic kidney disease (CKD) patients enrolled in a placebo-controlled, double-blind trial. This evidence concerns the gene SOD1 and chronic kidney disease.