Saldanha [203] reported no effect of 500 mg/d on NRF2 expression in peripheral blood mononuclear cells (PBMCs) of non-dialized CKD patients, whilst Seyyedbrahimi et al. [204] observed significant changes in NRF2 and SOD levels with 400 mg twice-daily in T2DM patients. This evidence concerns the gene NFE2L2 and type 2 diabetes mellitus.