Baj-Krzyworzeka et al. [215] showed that, carrying both proteins and mRNA, tumor cell-derived EVs activate monocytes, increasing the expression of human leukocyte antigen-DR isotype, IL-8, CCL2 and CCL4, production of ROS and secretion of TNF, IL-10 and IL-12p40. This evidence concerns the gene TNF and neoplasm.