Interestingly, in an in vitro study by Haga et al. [79], CX3CL1 was detected in the secretome of MSCs exposed to CCA cell-derived extravescicles (EVs), although untreated MSCs were unable to release this factor, further sustaining a contribution of this chemokine in CCA. The gene discussed is CX3CL1; the disease is cholangiocarcinoma.