We thus analyzed the expression of SigR1 mRNA in these HCA subtypes and found that the H-HCAs, which are caused by a bi-allelic inactivating mutation of HNF1α, showed significantly higher levels of SigR1 mRNA compared to non-tumoral liver and all other HCA subtypes (Figure 4A and Figure S2 for a detailed analysis). This evidence concerns the gene HNF1A and hepatocellular adenoma.