We demonstrated for the first time that knockdown of FBXL8 in BRCA cells: (i) suppressed cell survival via elevating intrinsic apoptosis, (ii) decreased cell migration and invasion, (iii) caused accumulation of tumor-suppressors, CCND2 and IRF5 and (iv) downregulated cancer-promoting cytokines and chemokines, hence curtailing the tumor microenvironment. The gene discussed is IRF5; the disease is cancer.