Previously, we demonstrated that Skp1-cullin-F-box proteins (SCF) E3 ubiquitin ligase critically balances immune-overactivation and pro-tumorigenesis [11,12], prompting us to hypothesize a vicious network of chronic inflammation-driven activation of SCF E3 ligase, which probably facilitates ubiquitination-mediated degradation of cancer-modulating factors and also perturbs the pro-tumorigenic cytokines. The gene discussed is KITLG; the disease is cancer.