FBXL8 and liver cancer: Figure S2 shows the clinicopathological parameters of the BRCA patient breast tissue samples used for qRT-PCR analysis. Consistently, the mRNA levels of FBXL8 were significantly elevated (p < 0.01) in primary BRCA tissues (Figure 2A). The expression levels of FBXL8 correlated significantly (p < 0.01) with clinical staging. In addition, SAG (sensitive to apoptosis gene), another important component of SCF E3 ubiquitin ligase, which confers anti-apoptosis and promotes liver cancer [12,23,24], was also significantly upregulated (p < 0.01) in all stages of BRCA (Figure 2B).