These anti-invasive properties of ectopically expressed AnxA6 in human squamous A431 epithelial carcinoma cells can be attributed to mislocalization of several SNARE proteins, including SNAP23, syntaxin 4 (Stx4) and Stx6, responsible for the secretion of fibronectin (FN) and the recycling of αVβ3 and α5β1 integrins, respectively [28,40]. This evidence concerns the gene FN1 and carcinoma.