ANXA6 and breast cancer: Indeed, in a quest to provide a comprehensive picture on the molecular mechanisms underlying the role of AnxA6 in breast cancer cell motility and proliferation, Whalen et al. identified RasGRF2, a Ras protein-specific guanine nucleotide exchange factor (RasGEF), as a major effector of AnxA6-mediated cell growth and motility [20].