In line with the oxidative stress response and extracellular matrix deposition, Stock et al. found that the SOD2 mRNA expression was markedly suppressed in both systemic sclerosis-ILD and IPF fibroblasts, compared with non-ILD controls, leading to an increasing trend in ACTA2 mRNA expression and cell proliferation [65]. The gene discussed is ACTA2; the disease is interstitial lung disease.