Although the rs11705701 G > A, rs4402960 G > T, and rs1470579 A > C polymorphisms of IGF2BP2 did not affect oral cancer susceptibility, our study of Taiwanese men with oral cancer revealed that people with the IGF2BP2 rs11705701 GA+AA, rs4402960 GT+TT, and rs1470579 AC+CC genotypes are more likely to have a more advanced clinical stage, larger tumor, and progression of lymph node metastasis. This evidence concerns the gene IGF2BP2 and metastatic malignant neoplasm in the lymph nodes.