TERF2 and Familial prostate cancer: In the total affected genes (4698), nine are associated with telomere maintenance (Gene Ontology term, GO:0000723) (ATM, PARP1, HNRNPC, RAD50, PINX1, TERF2, NAT10, HNRNPA1, and TNKS) (9 of 36 genes found in this pathway) and 18 genes were related to prostate cancer in the KEGG database (hsa05215) (18/89 found associated with prostate cancer) (Figure 5 in bold).