Analysis of the expression levels of the HH pathway genes in the 1457 cell lines in the Cancer Cell Line Encyclopedia (CCLE, https://portals.broadinstitute.org/ccle) showed a significant positive correlation (r = 0.37, p < 0.0001) between SMO and GLI2, supporting the conclusion that SMO gene regulation is important in HH pathway regulation (Figure S4). The gene discussed is SMO; the disease is cancer.