The serum level of OPG was elevated in patients with PCa-associated DM, and the receiver operating characteristic (ROC) curve revealed that serum OPG provided an AUC of 0.737 with a sensitivity of 68.0% and a specificity of 73.9% to distinguish PCa-associated DM from new-onset type 2DM. This evidence concerns the gene TNFRSF11B and posterior cortical atrophy.