GAST and pancreatic adenocarcinoma: As gastrin binds to CCK-2 receptor, the stimulated CCK-2 receptor activates several kinases and signaling pathways that are related to pancreatic adenocarcinoma upregulation [57]; some of them are the JAK2/STAT3 pathway [58], Src-related tyrosine kinases, and p125FAK, which play a crucial role in gastrin effects [59].