In particular, with a 10-year follow-up of 3306 participants in the Framingham study, it was found that 250 people (7.8%) had episodes of AF, while a higher level of circulating galectin-3 was associated with an increased risk of AF (OR = 1.19, 95% CI = 1.05–1.36, p = 0.03) [12]. This evidence concerns the gene LGALS3 and atrial fibrillation.