BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Two of them code for immunoglobulins, IGLC1 and IGLJ3. The third overexpressed gene is BCR. The cytoband 22p11 is well known to be involved in chromosomal abnormalities; BCR is directly involved in the reciprocal translocation with the ABL1 gene on Chr9 that produces the Philadelphia chromosome and forms the fusion transcript BCR-ABL1, strictly associated with the chronic myeloid leukemia (CML) [102,103].