EGFR and non-small cell lung carcinoma: Remarkably, IGF1R (insulin-like growth factor 1 receptor) mRNA and protein expression levels are directly correlated with shorter PFS and OS in NSCLC patients either with or without association to EGFR (epidermal growth factor receptor) [91,92], and Notch1 has been found to form a transcriptional complex in an Rbpjk-recognition motif located in intron 1 of IGFR and regulate its expression, along with Akt1 phosphorylation, downstream of HIF-1α [89], further confirming Notch1’s role as a main transducer hub for HIF-1α/Akt-1/IGFR molecular circuitry.