ASCL1 and neoplasm: Interestingly in SCLC cells, histone H3K27 acetylation of Notch1 promoter and its transcriptional activation occurs when they are subjected to LSD1 (lysine-specific histone demethylase 1A) inhibition, in an event that further conduces to repression of Ascl1 expression and reduced tumor cell viability [107].