NOTCH2 and non-small cell lung carcinoma: Critically, a recent study on NSCLC chemosensitivity and CSCs has shown that ectopic expression of microRNA miR-181b suppresses CSC-like characteristics including tumorsphere formation and tumorigenecity in vitro and in xenograft models, and that these effects were mediated through downregulation of Notch2 transcription via interference binding to its 3′-UTR [80].