JAG1 and non-small cell lung carcinoma: Notch ligands’ mutations have been less well studied/characterized in NSCLC primary tumors, although they have been found in various NSCLC cell lines, albeit with a relatively lower frequency than in Notch receptor genes [110], and the expression levels of these Notch non-cell autonomous factors have been observed to be consistently lower in NSCLC tumors compared to surrounding, non cancerous tissue, with increased Jag1 levels among NSCLC tumors serving, nonetheless, as an indicator of poor overall survival [111].