Interestingly, in the KrasG12D;Trp53flox/flox;eYFP murine model of NSCLC, a putative CSC population with augmented sphere forming ability was identified as markedly positive for CD24, ITGB4 (integrin subunit beta 4), and Notch1, Notch2 and Notch4 (CD24+ITGB4+Notchhi), and furthermore, actionably relevant in chemoresistance acquisition and functionally dependent on Notch3 action [74]. The gene discussed is ITGB4; the disease is non-small cell lung carcinoma.