NOTCH2 and non-small cell lung carcinoma: While the observations above are discernibly contrasting in regard to an oncogenic role for Notch2 in NSCLC initiation and progression, the inductive exertion of transition states in AT2 cells [83] and its implication in EMT [79], as well as its predominant function in AT2 cell maturation and differentiation [7], and the fact that AT2 cells have been shown to functionally serve as cells-of-origin of NSCLC [63,84] (Figure 2), strongly warrants further exploration into the cell-specific, gain- and loss-of-function effects of this receptor in postnatal lung function and oncogenesis.