BCL2 and neoplasm: In addition, another GSI, MRK-003 has been tested in xenograft models and been shown efficacious in reducing tumor growth through cell death induction via downregulation of levels of anti-apoptotic phospho-Bcl-2 and Bcl-xL [73], while monotherapy with GSI BMS-906024 had a significant (p < 0.05) specific spheroid growth delay in 3D spheroid forming assays [132].