Remarkably, it should be noted that while Notch3 mediates EGFR regulation of the Wnt/β-catenin pathway in EGFR mutant NSCLC, a dominant negative form of Mastermind-like (dn-MAML) is ineffective in preventing the expansion of ALDH+ CSCs in these tumors, indicating that Notch3 action is likely due to non-canonical activity [102]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.