Intriguingly, a recent study in 2437 NSCLC tumor samples found that higher levels of Notch1, Notch2, Jag1, and Dll1 mRNA were associated with better OS in ACL patients, while elevated Notch3, Jag2 and Dll3 mRNAs correlated with poor survival [81], and a report by Baumgart et al. showed that 67% of NSCLC tumors have either no or weak expression of Notch2 compared to normal lung tissue [82]. This evidence concerns the gene JAG1 and non-small cell lung carcinoma.