Noticeably, this latter work also disclosed that unlike Notch1 or Notch3, which displayed increased levels, Notch2 was decreased in advanced tumors in the KrasG12D NSCLC model, where it furthermore displayed a tumor suppressor function through modulation of the Wnt/β-catenin pathway [82]. This evidence concerns the gene NOTCH1 and non-small cell lung carcinoma.