NOTCH1 and acute lymphoblastic leukemia: In NSCLC, similarly to in T-ALL, activating mutations in the Notch1 gene were found in 10% of NSCLC cases, and the presence of these alterations, which occur in the heterodimerization and PEST domains, were associated with worse prognosis in NSCLC patients proficient for the tumor suppressor p53 [78].