Notably, in both ACL and T-ALL cells, HIF-1α has been shown to functionally act as an upstream positive regulator of Notch1 expression and action, and Notch1 has been ascribed as a molecular transducer for HIF-1α proliferative, pro-survival, and chemoresistance signals [89,90]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.