NUMB and neoplasm: Furthermore, there is evidence from signaling dynamics modeling and observations in breast cancer cells that suggests that Jagged-induced Notch activity may cause pushing circulating tumor cells to a survival-advantageous, epithelial/mesenchymal hybrid state [76], which, while it has been observed in NSCLC cells, it has, intriguingly, found to be destabilized and pushed towards full EMT upon Numb or Numbl silencing in hybrid state H1975 cells, thus indicating that Numb may act as a brake/modulating factor in EMT [77].