Clearly, further studies steered towards exploring Notch gain- and loss-of-function activity in the context of hyper-activated and inactivated ID1 would confirm the Lkb1/ID1/Notch molecular wiring in adenosquamous cell carcinoma formation and NSCLC progression, metastatic dissemination and therapy resistance. This evidence concerns the gene ID1 and non-small cell lung carcinoma.