Notably, Notch1, HIF-1α, and IGFR have been shown to be implicated in NSCLC EMT and CSC survival and self-renewal [93,94,95], and Notch1 has been found highly expressed in CD44+CD24− A549 CSCs, where its inhibition, through either siRNA or DAPT, markedly reduced colony-forming capacity [93]. This evidence concerns the gene IGF1R and non-small cell lung carcinoma.