Of marked importance, it has been determined that Kras-triggered murine NSCLC tumors display significantly higher levels of Notch1ICD and Hes1, which furthermore is associated with tumor grade [87], thus directly suggesting that, in the context of Kras-driven NSCLC, Notch may act as downstream mediator and, plausibly, as an actionable target. The gene discussed is HES1; the disease is non-small cell lung carcinoma.