CFTR and cystic fibrosis: Furthermore, all the 47 CF patients had two CFTR variants (Supplemental Table S1); in 44/47 (93.6%) cases, both the variants were disease-causing according to CFTR2 and to CFTR-France databases [11], while in 3/47 cases one variant was disease-causing and the other was not reported in the databases, i.e., H147P (1 case) and 1249-1G>A (2 cases).