Similarly, four of the eight patients that we diagnosed as CF-SPID at the newborn period who evolved into CFTR-RD (# 1, 3, 4, 6 in Table 5) also had a ST < 30 mmol/L, a single variant after first level analysis, among which the D1152H in four cases [22] and the second variant with undefined phenotypic consequences, i.e., Q1476X, L997F (2 cases) and S1426 F, were revealed by sequencing. This evidence concerns the gene CFTR and cystic fibrosis.