In summary, as shown in schema abstract of Figure 8, our results suggested that BC200 RNA, a lncRNA, is highly expressed both in vitro and in vivo and significantly modulates GB oncogenicity and enhances TMZ chemoresistance through concomitantly enhancing self-renewal and pluripotency of GB cells by modulating the expression of tumor-suppressor miR-218-5p. This evidence concerns the gene BCYRN1 and neoplasm.