KLK3 and Familial prostate cancer: A study by Palma and associates [81] highlights that prostate-specific antigen (PSA) screening would be beneficial in decreasing prostate cancer mortality, while Hallberg and associates [82] mention important points for developing an SD model for patients with growing tumors, which were (a) categorizing patients based on a physiological point of view, and (b) considering a non-constant rate for tumor growth.