In a genome-wide transcriptional profiling in memory CD4+ T-cells enriched in Th17 cells, Cleret Buhot et al. [51] identified a set of HIV dependency cellular factors, which are typically TCR signal molecules in Th17 cells versus Th1 cells, which could potentially be targeted as novel therapies aimed at protecting Th17 cells from HIV infections and the subsequent depletion in HIV-infected individuals. This evidence concerns the gene CD4 and HIV infectious disease.