PHGDH and breast carcinoma: Indeed, phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the pathway, is amplified in breast cancer and melanoma, where it functions as an oncogene (Locasale et al, 2011; Possemato et al, 2011) and the SBP is also the target of a series of oncogenes (Amelio et al, 2014; Yang & Vousden, 2016).