Beyond cancer, IKKε is a key regulator of both innate and adaptive immunity, activating NFκB and interferon regulatory factor 3 (IRF3), inducing type I interferon signalling (Clément et al, 2008; Zhang et al, 2016), although activation of the interferon response is not essential for IKKε‐mediated cellular transformation (Boehm et al, 2007). This evidence concerns the gene IRF3 and cancer.