Upon siRNA‐mediated knockdown of IKKε, downregulation of PSAT1 at the transcriptional level was observed in 5 out of 9 breast cancer cell lines tested (ZR‐75‐1, T47D, MDA‐MB‐468, Cal120 and HCC1143) (Fig 5A). This evidence concerns the gene IKBKE and breast carcinoma.