Currently a natural history study of diseases caused by pathogenic variants in the USH2A gene, called RUSH2A (NCT03146078) is following 127 patients over 4 years is in progress (Duncan et al., 2020) and a second study on people with pathogenic variants in the EYS gene called Rate of Progression in EYS Related Retinal Degeneration (Pro‐EYS) (NCT04127006), a cause of AR RP, is also in progress. The gene discussed is USH2A; the disease is retinitis pigmentosa 1.