We have previously shown that a single administration of the TGN-020 AQP4 inhibitor on an animal model of ischemic stroke reduces brain cytotoxic oedema by limiting the plasma influx into the parenchyma, and that this effect is associated with thicker vascular basement membranes in ischemic animals treated with TGN-020 [27]. Here, AQP4 is linked to ischemic stroke.