Concordantly, Arnesen et al showed that KCNJ5 somatic mutations were associated with a better surgical outcome in 28 APAs, which was confirmed recently by Vilela et al on 100 patients with unilateral PA, where somatic KCNJ5 mutation was an independent predictor of hypertension remission after adrenalectomy [148, 149]. The gene discussed is KCNJ5; the disease is hypertensive disorder.