Somatic alterations of PRKAR1A were also described in CPAs, with LOH in the PRKAR1A locus 17q found in 7 of the 29 studied adenomas and somatic-inactivating mutations in 3 CPAs responsible for overt Cushing syndrome [69]. This evidence concerns the gene PRKAR1A and Cushing syndrome due to macronodular adrenal hyperplasia.