Alterations of PDE11A and PDE8B were not specific of PPNAD and were further described in other types of adrenocortical tumors: PBMAH, adrenocortical adenomas (ACAs), nonsecreting adrenocortical adenoma and adrenocortical carcinomas (ACCs) [26-28]. The gene discussed is PDE8B; the disease is adrenal cortex adenoma.