PLT < 150 000 /μL was a marginal predictor of HCC occurrence in Cox proportional regression analysis (odds ratio: 3.80, 95% confidence interval: 0.85–17.00, P = 0.081), while male gender (odds ratio: 3.43, 95% confidence interval: 1.20–9.83, P = 0.021) and albumin <4.0 g/dL (odds ratio: 7.98, 95% confidence interval: 1.76–36.24, P = 0.007) were demonstrated to be independent risk factors of HCC occurrence. This evidence concerns the gene ALB and hepatocellular carcinoma.