The purpose for this article is to review the literature to highlight the role of the common anti-TNF agents, infliximab, adalimumab, and etanercept, in the management of extra-pulmonary sarcoidosis and non-infectious uveitis, summarize key articles comparing the efficacy and safety profile of these agents as well as discuss possible areas for future research. This evidence concerns the gene TNF and pulmonary sarcoidosis.