Figure 11 shows that the protein expression levels of p53, p-p53, and p21 significantly increased after DLGAP5 knockout in Capan-2 and SW1990 cells, suggesting that the p53 pathway is activated in pancreatic cancer cells after DLGAP5 knockout, which may inhibit the malignant phenotypes of pancreatic cancer cells. The gene discussed is TP53; the disease is familial pancreatic carcinoma.