DLGAP5 and familial pancreatic carcinoma: Figure 11 shows that the protein expression levels of p53, p-p53, and p21 significantly increased after DLGAP5 knockout in Capan-2 and SW1990 cells, suggesting that the p53 pathway is activated in pancreatic cancer cells after DLGAP5 knockout, which may inhibit the malignant phenotypes of pancreatic cancer cells.